上海老年脑健康队列研究
上海东方脑医学基金会
主要PI
  • 肖世富

    上海东方脑医学基金会理事长、上海市精神卫生中心老年病科主任,上海交通大学阿尔茨海默病诊治中心主任

肖世富,1961年出生,医学博士,主任医师、教授、博导。毕业于上海第二医科大学(现上海交通大学医学院)。现任上海市精神卫生中心(上海交通大学医学院附属精神卫生中心)老年病科主任,上海交通大学阿尔茨海默病诊治中心主任。

学术兼职:
上海东方脑医学基金会理事长,中国医师协会老年医学医师分会副会长,中国老年痴呆及相关病协会副主任委员,中国心理卫生协会心理评估专业委员会副主任委员,中国老年保健研究会老年认知与心理疾病分会常委,中国微循环学会神经变性病专业委员会常委,中国残疾人康复协会心理康复专业委员会常委,中华老年医学会教育委员会委员,中国老年学会老年医学专家委员会委员,中华神经科学会痴呆与认知障碍学组委员,中国神经科医师分会认知障碍学组委员。国家药审中心评审专家,卫生部医学科技发展研究中心临床医学专家委员会委员。上海市老年医学医师分会副会长,上海市神经科学学会理事,上海市老年医学会委员,上海市老年学会委员,上海市老年保健专家委员会委员,上海市高级职称评审委员会评审专家。曾任中华精神科学会委员及老年学组副组长,国际老年神经精神药理学会委员,上海市精神医学会委员,上海市心理卫生学会理事。担任多本中外专业杂志的副主编或编委。

科研:
近年主持或参与的主要研究:国家科技部重大新药创制课题1类靶向Aβ抗阿尔茨海默病药物971的III期临床及产业化研究(2015-2018年,负责人);国家科技部重大新药创制课题1类新药琥珀吖啶治疗阿尔茨海默病III期临床研究(2016-2019年,责任人);上海市科委2015年度“科技创新行动计划”国际合作项目课题神经影像学检测技术对1类抗阿尔茨海默病药物971临床疗效的客观评价研究(2015-2016年,负责人);上海交通大学医学院与中科院神经所脑疾病中心课题,阿尔茨海默病的早期识别、诊断与炎症发病机制(2015-2018年,负责人);国家自然科学基金国际合作重大课题老年期痴呆早期诊断的神经影像研究(2013-2017年,子课题负责人)等。

获奖:
(1)获教育部科技进步一等奖1次;(2)上海市科技进步二等奖2次, 获粟宗华精神卫生二等奖2次;(3)上海市医学科技三等奖1次;(4)获WHO中国神经科学优秀论文奖、全国中青年优秀医学论文奖、中华精神科学会优秀论文奖等国内外各级优秀论文奖10余次;(5)1998年入选上海市医学跨世纪学科带头人百人计划;(6)国务院特殊津贴;(7)上海市卫生局行政记大功1次;(8)全国优秀精神科医师,上海市卫生系统银蛇奖,上海市卫生系统先进工作者;(9)国内外发表论文200余篇,其中SCI收录论著73篇,主编和参编专著30余本。

近3年代表论文:(*: corresponding author)

  1. Yue Ling, Wang Tao, Wang Jingyi, Li Guanjun, Wang Jinghua, Li Xia, Li Wei, Hu Mingxing, Xiao Shifu*. Asymmetry of Hippocampus and Amygdala Defect in Subjective Cognitive Decline Among the Community Dwelling Chinese. Frontiers in Psychiatry. 2018;9(2018):226.
  2. Xiao Shifu, Wang Tao, Ma Xiuqiang, Qin Yingyi, Li Xia, Zhao Zhongxin, Liu Xueyuan, Wang Xiaoping, Xie Hengge, Jiang Qinpu, Sun Li, Luo Benyan, Shang Lan, Chen Weixian, Bai Yan, Tang Muni, He Maolin, Wu Lan, Ma Qilin, Hou Deren, He Jia. Efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate Alzheimer's disease: a Phase II multicenter randomised controlled trial. Age and Ageing. 2017;46:767-773.
  3. Wang Tao, Shi Feng, Jin Yan, Jiang Weixiong, Shen Dinggang, Xiao Shifu*. Abnormal Changes of Brain Cortical Anatomy and the Association with Plasma MicroRNA107 Level in Amnestic Mild Cognitive Impairment. Frontiers in Aging Neuroscience. 2016;8(2016):112.
  4. Sun L, Li X, Lin X, Yan F, Chen K, Xiao S*. Familial fatal insomnia with atypical clinical features in a patient with D178N mutation and homozygosity for Met at codon 129 of the prion protein gene. Prion. 2015 May 4;9(3):228-235.
  5. Yang C, Xiao S*. New developments of clinical trial in immunotherapy for Alzheimer's disease. Curr Pharm Biotechnol. 2015;16(6):484-491.
  6. Wang T, Chen K, Li H, Dong S, Su N, Liu Y, Cheng Y, Dai J, Yang C, Xiao S*. The feasibility of utilizing plasma miRNA107 and BACE1 messenger RNA gene expression for clinical diagnosis of amnestic mild cognitive impairment. J Clin Psychiatry. 2015 Feb;76(2):135-141.
  7. Cheng Y, Xiao S*. Recent research about mild cognitive impairment in China. Shanghai Arch Psychiatry. 2014 Feb;26(1):4-14.
  8. Xu X, Xiao S, Rahardjo TB, Hogervorst E. Tofu intake is associated with poor cognitive performance among community-dwelling elderly in China. J Alzheimers Dis. 2015;43(2):669-675.
  9. Zhu M, Xiao S*, Li G, Li X, Tang M, Yang S, Xu X, Feng L, Liu K, Hu L. Effectiveness and safety of generic memantine hydrochloride manufactured in China in the treatment of moderate to severe Alzheimer's disease: a multicenter, double-blind randomized controlled trial. Shanghai Arch Psychiatry. 2013 Aug;25(4):244-253.
  10. Sun L, Guo C, Wang T, Li X, Li G, Luo Y, Xiao S*. LIMK1 is involved in the protective effects of bone morphogenetic protein 6 against amyloid-β-induced neurotoxicity in rat hippocampal neurons. J Alzheimers Dis. 2014;42(2):543-554.
  11. Wang T, Xiao S*, Liu Y, Lin Z, Su N, Li X, Li G, Zhang M, Fang Y*. The efficacy of plasma biomarkers in early diagnosis of Alzheimer's disease. Int J Geriatr Psychiatry. 2014 Jul;29(7):713-719.
  12. Kapoula Z, Yang Q, Otero-Millan J, Xiao S, Macknik SL, Lang A, Verny M, Martinez-Conde S. Distinctive features of microsaccades in Alzheimer's disease and in mild cognitive impairment. Age (Dordr). 2014 Apr;36(2):535-543.
  13. Wang T, Huang Q, Reiman EM, Chen K, Li X, Li G, Lin Z, Li C, Xiao S*. Effects of memantine on clinical ratings, fluorodeoxyglucose positron emission tomography measurements, and cerebrospinal fluid assays in patients with moderate to severe Alzheimer dementia: a 24-week, randomized, clinical trial. J Clin Psychopharmacol. 2013 Oct;33(5):636-642.
  14. Li X, Xiao S*, Fang Y, Zhu M, Wang T, Seeher K, Brodaty H. Validation of the General Practitioner Assessment of Cognition - Chinese version (GPCOG-C) in China. Int Psychogeriatr. 2013 Oct;25(10):1649-1657.
  15. Haibo Xue, Shifu Xiao, Ng Tze Pin, Chao Chen, Guorong Meng, Xuejue Lu, Shiming Bu, Wenli Fang, Jun Lv, Mingyuan Zhang, Marita P McCabe. Prevalence and severity of behavioral and psychological symptoms of dementia (BPSD) in community dwelling Chinese: findings from the Shanghai three districts study. Aging Ment Health. 2013;17(6):748-752.
  16. Xiao S*, Li J, Tang M, Chen W, Bao F, Wang H, Wang Y, Liu Y, Wang Y, Yuan Y, Zuo X, Chen Z, Zhang X, Cui L, Li X, Wang T, Wu W, Zhang M. Methodology of China's national study on the evaluation, early recognition, and treatment of psychological problems in the elderly: the China Longitudinal Aging Study (CLAS). Shanghai Arch Psychiatry. 2013 Apr;25(2):91-98.
  17. Yang Q, Wang T, Su N, Xiao S*, Kapoula Z. Specific saccade deficits in patients with Alzheimer's disease at mild to moderate stage and in patients with amnestic mild cognitive impairment. Age (Dordr). 2013 Aug;35(4):1287-1298.
  18. Xiao S*, Xue H, Li G, Yuan C, Li X, Chen C, Wu HZ, Mitchell P, Zhang M. Therapeutic effects of cerebrolysin added to risperidone in patients with schizophrenia dominated by negative symptoms. Aust N Z J Psychiatry. 2012 Feb;46(2):153-160.
  19. Wang T, Xiao S*, Li X, Wang H, Liu Y, Su N, Fang Y. Reliability and validity of the Chinese version of the neuropsychiatric inventory in mainland China. Int J Geriatr Psychiatry. 2012 May;27(5):539-544.
  20. Wang T, Xiao S*, Li X, Ding B, Ling H, Chen K, Fang Y. Using proton magnetic resonance spectroscopy to identify mild cognitive impairment. Int Psychogeriatr. 2012 Jan;24(1):19-27.